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Intermediates for APIs

Acebutolol
ACE-3: 2-acetyl-4-butyramidophenol
ACE-4:2-epoxymethoxy-5-butyramido acetophenone

Adefovir Dipivoxil
Hydroxymethyl phosphonic acid diethyl ester
Diethyl p-toluenesulfonyloxymethyl phosphonate

Aliskiren
(E,2S,7R)-7-(3-(3-methoxypropoxy)-4-methoxybenzyl)-2-isopropyl-N,N, 8-trimethyl non-4-enamide CAS : 324154-26-5
(E,2S,7R)-methyl-7-(3-(3-methoxypropoxy)-4-methoxybenzyl)-2-isopropyl-8-methylnon-4-enoate CAS: 387353-71-1
(3S,5S)-5-[(1R,3S)-1-bromo-3-[[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl]-4-methylpentyl] dihydro-3-(1-methylethyl)-2-(3H)-furanone CAS : 393108-57-1
(3S,5S)-5 ((1S,3S)-3-(3-(3-methoxypropoxy)-4-methoxybenzyl)-1-azido-4-methylpentyl)-dihydro-3- isopropylfuran-2(3H)-one CAS : 324763-46-4

Anastrozol
2,2'-(5-Metheyl-1,3-phenylene)-di-(2-methylpronitrile) CAS :120511-72-0
2,2'-(5-Bromomethyl -1,3-phenylene)-di-(2-methylpronitrile) CAS: 120511-84-4

Aripiprazole
3,4-Dihydro-7-Hydroxy-2(1H)-Quinolinone CAS No. 22246-18-0
7-(4-Bromobutoxy)-3,4-Dihydro-2(1H)-quinolinone CAS NO. 129722-34-5
3,4-Dihydro-7-(4-chlorobutoxy)-2(1H)-quinolinone CAS 120004-79-7
1-(2,3-Dichlorophenyl) piperazine Hydrochloride CAS NO. 119532-26-2

Atorvastatin
ATS-4 CAS NO.86728-85-0 ATS-5 CAS NO.141942-85-0 ATS-8 CAS NO.12571-94-0
ATS-9 CAS NO.125995-13-3 MDEB CAS NO.7397-46-8
M4 CAS NO. 125971-96-2 L-1 CAS NO. 125971-95-1

Aspoxicillin
D-Aspartic Acid AJI 92

Bepotastine
2-{s-(4-Clphenyl)(4-Piperidinyloxy)Me}Pyridine (CAS: 201594-84-5)

Bicalutamide
4-Cyano-3-trifluoromethyl aniline CAS NO. 654-70-6
N-[4-Cyano-3-trifluoromethy phenyl]-2-oxirane carboxamide CAS NO. 90357-51-0
N-[4-Cyano-3-trifluoromethy phenyl]-S-(4-fluorophenylthio)-2-hydrdoxy-2-methyl-propionamide CAS NO. 90356-78-8

Bisoprolol
4-[[2-(1-methylethoxy)ethoxy]methyl]Phenol CAS No. 177034-57-0

Candesartan Cilexetil
2-Cyano-4'-Bromomethyl Biphenyl CAS NO.114772-54-2 

Triphenylmethyl Chloride CAS NO. 76-83-5
N-(Trityl)-5-(4'-Bromomethyl Biphenyl-2-Yl)-Tetrazole CAS NO.124750-51-2 

Trityl Candesartan CAS NO.139481-59-7
Trityl Candesartan Cilexetil CAS NO. 170791-09-0

Capecitabine
1,2,3-triacetoxy-5-deoxy-D-ribose CAS No: 62211-93-2
2',3'-di-O-acetyl-5'-deoxy-5-fluorocytidine CAS No. 161599-46-8
5'-deoxy-5-fluoro-N-[(pentyloxy)carbonyl]cytidine 2',3'-diacetate CAS No. 162204-20-8

Carticane
Methyl 3 Amino 4 Methyl Thiophene 2 carboxylate

Celecoxib
4,4,4-Trifluoro-1-(4-Methylphenyl)-1,3-Butanedione
4-Hydrazinobenzenesulfonamide HCl

Cinacalcet HCl
3-(Trifluoromethyl) Cinnamic Acid

Dapoxetine
(S)-3-amino-3-phenylpropionic acid CAS no.614-19-7
(S)-3-amino-3-phenylpropan-1-ol CAS no.82769-76-4
(S)-n,n-dimethyl-3-(naphthalene-1-yloxy)-1-phenylpropan-1-amine hydrochloride CAS no.129938-20-1

Dichlofenac sodium
1-(2,6-Dichlorophenyl)indolinone-2-one

Doneperzil
5,6-Dimethoxy-1-indanone CAS NO.2107-69-9
4-pyridine carboxyaldehyde CAS NO.872-85-5
5,6-Dimethoxy-2-(pyridine-4-yl)methylene-indan-1-one CAS NO.4803-74-1
5,6-Dimethoxy-2-(piperidin-4-yl)methyl-indan-1-one CAS NO.120014-30-4
2,3-Dihydro-5,6-dimethoxyl-2-((piperidin-4-yl)methyl)indan-1-one CAS NO.120013-39-0
2,3-dihydro-5,6-dimethoxy-2-{[1-(phemylmethyl)-4-piperidinyl]methyl}-1H-indan-1-one HCL CAS#:120011-70-3
1-Benzyl-4-[(5,6-dimethoxy-1-indanone)-2-yl]methylpiperidine CAS#:120014-06-4

Dapoxetine
(S)-3-amino-3-phenylpropionic acid CAS no.614-19-7
(S)-3-amino-3-phenylpropan-1-ol CAS no.82769-76-4
(S)-n,n-dimethyl-3-(naphthalene-1-yloxy)-1-phenylpropan-1-amine hydrochloride CAS no.129938-20-1

Doxepin
11-dihydrodibenz[b,c]oxcpin-11-one
11-(3-dimethylaminopropyl-6,11-dihydrodibenz[b,c]oxcpin-11-ol

Efavirenz
Lithium metal
N-Butyl lithium
Cyclopropyl acetylene CAS no.6746-94-7
Cyclopropylethanone CAS no.765-43-5
E1: N-[2,2-dimethyl propanoyl]para chloro aniline CAS no.65854-91-3
E2: 4-Chloro-2-trifluoro acetyl aniline HCL CAS NO. 173676-59-0
E3: N-[(4'-methoxy) benzyl]-4-chloro-2-trifluoroacetyl aniline CAS no.173676-54-5
E4: (R)-2-(2-(4-methoxybenzylamino)-5-chlorophenyl)-4-cyclopropyl-1,1,1-trifluorobut-3-yn-2-ol

Enofloxacin
2,6-Dichloro-5-fluoro-3-pyridinecarbonitrile
2,6-Dichloro-5-fluoro Nicotinic Acid
Ethyl-2,6-dichloro-5-fluoro Nicotinyl Acetate

Epinastine
6-aminoethy1-6,11-dihgdro-5H-dibenz[b,e]azepine salt
6-cyano-11H-dibenz[b,e]azepine

Erlotinib hydrochloride
6,7-bis-(2-Methoxyethoxy)-quinazolin-4(3h)-one CAS: 179688-29-0
4-Chloro-6,7-(2-methoxyethoxy)-quinazoline CAS: 183322-18-1

Etodolac
7-Ethyl Tryptophol
Etodolac Methyl Ester

Flecainide
2,5-Bis-(2,2,2-Trifluoroethoxy) benzoic acid

Fluoxetine
3-Methylamino-1-Phenyl Propane-1-ol

Finasteride
Methyl-3-oxo-4-androstene-17-beta-carboxylate
F7:17-beta-(n-butylcarbamoyl)-5-oxo-3,5-secoandrostan-2-oic acid ( cas no.190006-01-0)
F8:17-beta-(n-butylcarbamoyl)-4-aza-5-alpha-androsten-3-one(cas no.166896-74-8)
F9:17-beta-(n-butylcarbamoyl)-4-aza-5-alpha-androstan-3-one( cas no.98319-24-5)
FS6

Fluvoxamine
1-chloro-4-methoxy butane
5-methoxy-1-(4-thifluoromethylphenyl) Pentanone

Flavoxate Hydrochloride
3-Methylflavone-8-carboxylic acid CAS no. 3468-01-7

Folic acid
2,4,5-Triamino-6-hydroxy pyrimidine sulfate CAS NO.16030-02-7

Gabapentine
1,1-Cyclohexane Diacetic Acid (CDA)
1,1-Cyclohexane Diacetic Acid Monoamide (CAM)

Gemcitabine Hydrochloride
2-Deoxy-2,2-difluoropentofuranos-1-ulose-3,5-dibenzoate CAS:122111-01-7
2-Deoxy-2,2-difluoro-D-erythro-pentofuranose-3,5-dibenzoate-1-methanesulfonate CAS:122111-11-9

Gemfibrozil
2,5-xylenol CAS NO.95-87-4
Isobutyl 5-chloro-2,2'-dimethyl valerate CAS NO.109232-37-3
2,2-Dimethyl-5-(2,5xylyloxy) valeric isobutyl ester CAS NO.149105-26-0

Glimepiride
N-(4-Aminosulfonyl phenyl) ethyl aminomethyl-3-Ethyl-4-Methyl-2-Pyrollidone
Trans-4-Methyl Cyclohexylamine
Trans-Isocyanate-4-Methyl Cyclohexane

Granisetron HCL
1H -Indazole-3-carboxylic acid
1H -Methylindazole-3-carboxylic acid CAS NO.50890-83-0
Endo-9-methyl-9-azabicyclo[3,3,1]nonan-3-amine CAS NO.76272-56-5

Imatinib mesylate
4-[(4-Methyl-1-piperazinyl)methyl]benzoic acid dihydrochloride hemihydrate CAS :106261-49-8
N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamine CAS : 152460-10-1

Iopamidol
5-Amino 2,4,6-Tri Iodo Iso Phthalic Acid
L-2-Acetoxy Propionyl Chloride
Serinol (2-Amino-1,3-Propanediol )

Irinotecan
7-ethyl-10-(chlorocarbonyloxy) camptothecin
10-hydroxy Camptothecin
Camptothecin

Lamotrigine
(2,3-Dichlorophenyl)-Guanidinylimino Acetonitrile

Lamivudine
1.L-Menthyl glyoxylate hydrate
2.(2r,5r)-5-hydroxy-[1,3]oxathiolane-2-carboxylic acid,2s-isopropyl-5r-methyl-1r-cychlohexyl ester( HME)
3.(2R,5R)-5-(4-Amino-2-oxo-2h-pyridmidin-1-yl)-[1,3] oxathiolane-2-carboxylic acid, 2s-isopropyl-5r-methyl-1r-cyclohexyl ester(CME)
4.4-Amino-1-(2r-hydroxymethyl-[1,3]oxathiolan-5s-yl)-1H-pyrimidin-2-one monosalicylate( lamivudine salicylate)

Lansoprazole
2-Chloromethyl-3-Methyl-4-(2,2,2-Trifluoroethoxy) Pyridine HCl
2-Mercapto Benzimidazole

Levocetirizine
(-)1-[1-(4-chlorophenyl) phenylmethyl]piperazine CAS NO:130018-88-1

Levetiracetam
Ethyl-2-bromo butyrate
Methyl-2-bromo butyrate
(s)-2-amino butyramide
(R)-alpha methyl benzylamine salt
(Alpha-s)-alpha-ethyl-2-oxo-1-pyrrolidine acetic acid

Loratidine
N-methyl-4-chloro piperdine HCL
2-cyano-3-methyl pyridine
2-Cyano,3[2(3,Chlorophenyl)] Ethyl Pyridine
4-(3-ethyl[b-Chlorophenyl-pyridine-2-Carboxy]-1-methyl Piperdine

Losartan
OTBN
BCFI

Meloxicam
2-Amino-5-methylthiazole CAS NO.7305-71-7
2-Methyl-4-Hydroxy-2H-1,2-Benzothiazine-3-Carboxylic Acid Ethyl ester -1,1-Dioxide CAS NO.113913-36-3

Meprobamate
2-Methyl-2-Propyl-1,3-Propane Diol
Methyl Dopa
Veratraldehyde,
L-Amino Nitrile HCl

Meropenem/Imipenem/Faropenem
Acetoxyazetidinone CAS no.76855-69-1
(3S,4S)-4-[(R)-1-carboxy-ethyl]-3-[(R)-1-(t-butyldimethylsilyloxy)ethyl]-2-azetidinone CAS no.90776-58-2
(4R,5S,6S)-3-(diphenyl- oxy)phosphoryloxy-6-[(1R)-1-hydroxyethyl]- 4-methyl-7-oxo-1-azabicyclo[3,2,0]hept-2-
ene-2-carboxylate CAS no.90776-59-3
(2S,4S)-2-( dimethylamino- carbonyl)-4-mercapto-1-(p-nitrobenzyloxycarbonyl)-1-pyrrolidine -1-(p-nitrobenzyloxycarbonyl)-1-pyrrolidine CAS no.96034-64-9
[5R-(5α,6α(R*))]-6-(1-hydroxyethyl)-3,7-dioxo-1-azabicyclo[3.2.0]he-ptane-2-carboxylic acid (4-nitrophenyl)methyl ester CAS no.74288-40-7

Methyl Dopa
Veratraldehyde
L-Amino Nitrile

Mirtazapine
1-(3-Carboxypyridin-2-yl)-2-Phenyl-4-Methyl Piperazine
1-(3-Hydroxymethylpyridin-2-yl)-2-Phenyl-4-Methyl Piperazine

Mosapride Citrate
4-Amino-5-chloro-2-ethoxy- benzoic acid CAS NO. 108282-38-8
2-Aminomethy- 4-(4-fluorobenzyl)- morpholine CAS NO. 174561-70-7
4 –Amino-5-chloro-2-ethoxy-N-((4-(4-fluorobenzyl)-2-morpholinyl)methyl)benzamide

Montelukast Sodium
1,1-Cyclopropane Dimethanol
Methyl-2-Iodo Benzoate
MTS-4 : 1-(Mercaptomethyl)-Cyclopropane Acetic Acid CAS No.162515-68-6
Methyl-(2-Bromo Methyl) Benzoate
MTN-6: Methyl [E]-2-[3-[3-[2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-3-oxopropyl]benzoate CAS No.133791-17-0
MT-8: [(S)-(E)]-2-[3-[3-[2-(7-Chloro-2-Quinolinyl)Ethenyl]Phenyl]-3-HydroxyPropyl]-Phenyl]-2-Propanol CAS No.142569-70-8

Montelukast sodium ( Chinese patent route)
1-(3-(2-(7-chloro-2-quinolinyl) ethenyl)ethenyl) vinyl alcohol
Benzoic acid 2-(3-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-(3-carbonyl) propyl) –methyl ester, CAS 133791-17-0
Benzoic acid 2-(3-(R)-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-hydroxy propyl) –methyl ester, CAS 142569-69-6
Benzoic acid 2-(3-(R)-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-(acetyl mercapto)propyl) –methyl ester

Moxifloxacin
Pyridine 2,3-dicarboxylic acid
2,3-Pyridine dicarboxylic anhydride
(s,s)-2,8-diazabicyclo(4,3,0)nonane
7-Chloro-6-fluoro-1-cyclopropyl-1,4-dihydrogen-4-oxo-3-quinoline carboxylic acid

Nevirapine
2-Chloro-3-amino-4-methyl pyridine

Olanzapine:
4-Amino-2-Methyl-10H-Thieno-[2,3-b][1,5] Benzodiazepine HCl (CAS 138564-60-0)

Oxymetazoline:
6-Tert. Butyl-2,4-Xylenol

Pantoprazole
2-Chloromethyl-3,4-Dimethoxy Pyridine HCl
5-Difluoromethoxy-2-Mercapto-1H-Benzimidazole
4-chloro-3-methyxo-2-methyl pyridine N-Oxide
5-Difluoromethoxy-2-[[(3,4-dimethoxy-2-pyridnyl)methyl]thio]-1-H-benzimidazole
5-difuloromethoxy-2-[[(4-chloro-3-methoxy-2-pyridinyl)methyl]thio]-1-H-benzimidazole

Palonosetron
S-3 Aminoquinuclidine dihydrochloride [CAS no. 119904-90-4]
(S)-1,2,3,4-Tetrahydro Naphthoic Acid [CAS No. 85977-52-2]

Paroxetine HCl
3,4-(Methylenedioxy) phenol / sesamol CAS NO. 533-31-3
(3S,4R)-1-Methyl--3-[(3,4-(methylene-dioxy)phenoxy)METHYL]-4-(4-fluorophenyl) piperidine CAS : 61869-08-7
(-)-Trans-1- Methyl-3-Hydroxymethyl-4- (4-fluorophenyl) piperidine CAS : 109887-53-8
(3R,4S)4-(4'-fluorophenyl-3-hydroxymethyl-1-methyl) piperidine CAS: 105812-81-5

Perindopril
L-Norvaline ( cas no.6600-40-4)
(s)-(-)indoline-2-carboxylic acid
N-((S)-Ethoxycarbonyl-1-butyl)-(S)-alanine / N-((S)-1-carbethoxybuty l)-(S)- alanine
(2s,3as,7as)-2-carboxy octahydro indole/ (2S,3aS,7aS)octahydro- 1H- indole- 2- carboxylic acid

Pranlukast
4-(4-phenylbutoxy)benzoic acid
8-amino-4-oxo-2-tertrazol-5-yl-4H-1-benzopyran HCl

Pregabalin
(R)-(-)-3-Carbamoylmethyl-5-Methylhexanoic Acid CAS 181289-33-8

Quetiapine Fumarate
1-hydroxyethylethoxypiperazine CAS NO.13349-82-1
10,11-Dihydro-11-oxodibenzo[b,f][1,4]thiazepine CAS NO.3159-07-7
2-[2-(1-Piperazinyl)ethoxy]ethanol CAS NO.13349-82-1
2-(2-chloroethoxy) ethanol CAS NO. 628-89-7
11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride CAS NO.111974-74-4

Raloxifene
4-(2-Piperidinoethoxy)benzoic acid HCl (CAS 84449-80-9)
6-Methoxy-2-(4-Methoxyphenyl)benzo [b]thiophen (CAS 63675-74-1)

Ramipril
L-Serine Methyl Ester Hcl
(S,S)-2-Azabicyclo[3,3,0]-octane-3-carboxylic acid Benzylester Hydrochloride CAS NO.93779-29-4
(+/-) Octahydro cyclpenta[b]pyrrole-2-carboxylic acid HCl CAS NO. 93779-30-7
(S,S,S)-2-Azabicyclo[3,3,0]-octane-3-carboxylic acid Benzylester Hydrochloride

Rosjiglitazone:
2,4—thiazolidinedione
2-[N-methyl-N-(2-puridinyl) amino] ethanol

Sarpogrelate
Phenol,2[2(3-methoxyphenyl)ethyl] [Cas: 167145-13-3]

Sertraline
4-(3,4-dichlorophenyl)-3,4-dihydronaphthalen-1(2H)-one
4-(3,4-dichlorophenyl)-3,4-dihydro-1(2H)-N-methyl naphthalenamine

Sumatriptan
4-hydrazino n-Methyl benzene methanesulfonamide HCl

Sildenafil
N-methyl Piperazine
Sodium Methoxide powder
2-Pentanone (Methyl propyl Ketone)

Sumatriptan / Zolmtripan / Rizatriptan,
1) 4-chlorobutyraldehyde diethyl acetal / cas no. 6139-83-9
2) 4-chlorobutyraldehyde dimethyl acetal / cas no. 29882-07-3
3) 4-dimethylamino butyaldehyde diethyl acetal / cas no. 3616-56-6
4) 4-dimethylamino butyaldehyde dimethyl acetal / cas no. 1116-77-4 u
5) 4-amino butyraldehyde diethyl acetal / cas no. 6346-09-4
6) 4-chloro-1-hydroxy-1-butane sulfonate sodium / cas no. 54322-20-2
7) 4-aminophenyl-n-methylbenzene mathane sulfonamide / cas no. 109903-35-7
8) 4-hydrazinophenyl-n-methyl methane sulfonamide Hcl / cas no. 88933-16-8
9) (s)-4-(4-aminobenzyl)-1,3-oxazolidin-2-one / cas no. 152305-23-2
10) 4-(1H-1,2,4-triazol-1-yl-methyl) benzeneamine / cas no. 119192-10-8

Tamsulosin
2-(2-Ethoxyphenoxy)Bromide Ethane (CAS: 3259-03-8)
R-(-)-5-(2-Amino-Propyl)-2-Methoxy-Benzenesulfonamide (112101-81-2)

Telmisartan
4-Amino-3-Methyl Benzoic Acid Methyl Ester
N-Methyl Ortho Phenyl Diamine DiHCl
4'-BromoMethyl Biphenyl-2-Carboxylic Acid Methyl Ester
2-N-propyl-4-Methyl-6-(1-methyl benzimidazole-2-yl) benzimidazole

Temocapril
(2S,6R)-6-Amino-5-oxo-2-(2-thienyl)perhydro-1,4-thiazepine : [110221-26-6]

Tenatoprazole
2,3-dimaino-6-methoxy pyridine
2-mercapto-5-methoxy imidazole[4,5-b] pyridine

Timolol
3,4-Dichloro-1,2,5-Thiadiazole
S-(-)-t-Butylamino-1,2-Propanediol

Tinoxicam
Methyl-3-Sulfonyl amino methyl acetate-2-Thiophene Carboxylate (TCMC)
Topiramate
2,3,4,5-Di-O-iso propylidene-b-D-fructo pyranose (CAS:20880-92-6)

Trandolapril
(2S,3aR,7aS)-1H-octahydroindole-2-carboxylic acid Hydrochloride 144540-75-0

Trimetazidine
Gallic Acid

Verapamil, Bevantolol
Homoveratronitrile CAS No. : 93-17-4
Homoveratric acid CAS 93-40-3
Homoveratrylamine CAS 120-20-7

Venlafaxine
1-(2-Amino-(p-methoxyphenyl)-ethyl)-cyclohexanol HCl

Xylometazoline
2,3-Dimethyl-4-Terbutyl Phenylacetonitrile

Zidovudine
Stage III 5-O-GRIPHENYL-2-,3-DIDEHYROTHYMIDINE
Stage IV 3-AZIDO-3-DEOXY-5-O-TRIPHENYLMETHYL THYMIDINE

Zonisemide
4-hydroxy coumarine
2-(1,2-Benzisoxazol-3-yl)acetic acid CAS NO.4865-84-3
1,2-benzisoxazole-3-methane sulfonate sodium

Zopiclone
Pyrazine-2,3-Dicarboxylic acid
2-Amino-5-Chloro Pyridine

 

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